Yes Thanos will be back once again , but this time in the Infinity story arc.
It is going to be a six issues in the main story arc that starts in August. Detailing the war out in the universe You will see some of your favorite heroes in these issues like ; The Avengers , Thanos , Nova , Guardians of the Galaxy , and The Inhumans. This story arc began on Free Comic Book Day when the Prolouge began.
The prelude to this story begins in Avengers volume 5 issues 14 - 17. So be on the lookout. Lets see what craziness will begin in space now that Thanos is back!!!!